Can I take TYLENOL Extra Strength on an empty stomach?
TYLENOL® can be taken on an empty stomach. TYLENOL® may be a safe over the counter pain reliever for those with a history of stomach bleeding, stomach ulcers, or stomach problems such as heartburn. TYLENOL® is not an NSAID.
You can take Tylenol on an empty stomach, but make sure to take it with a full glass of water. Tylenol is safer for your stomach than NSAIDs like Advil or Motrin (ibuprofen), which can cause stomach bleeding or ulcers. Most adults can safely take up to 4,000 mg of regular strength Tylenol in a day.
A good rule of thumb is to be careful with any pain medication. Other than acetaminophen, patients taking medications for pain should do two things: First, take a full glass of water with these medications to wash them down. Second, do not lie down for 30-60 minutes after taking these pills.
- Skin swelling (angioedema)
- Hives.
- Low levels of red blood cells, white blood cells, and/or platelets.
- Disorientation.
- Shortness of breath.
- Cough.
- Liver toxicity/liver failure.
- Severe allergic reaction (anaphylaxis)
With Extra Strength Tylenol, patients can take 2 pills (each of which contains 500 mg of acetaminophen) every 4 to 6 hours; however, they should not take more than 8 pills in a 24-hour period.
To appreciate how easy it is to exceed the safe limit, consider that one extra strength Tylenol tablet contains 500 mg of acetaminophen. Take two tablets at a single dose three times a day and you are at the maximum recommended dose.
In the stomach, NSAIDs inhibit cyclooxygenase-1 (COX-1) 5
This can lead to GI side effects such as irritation and bleeding. Because TYLENOL® does not interfere with COX-1 like NSAIDs, it does not irritate the stomach the way naproxen sodium or even ibuprofen can.
Eat neutral foods
Crackers, rice, bread, peanut butter, and other neutral foods do a good job coating your stomach and prompting digestion, which helps your body to metabolize your medication efficiently.
Do not lie down immediately after taking medicine, to make sure the pills have gone through the esophagus into the stomach. Notify your healthcare provider if you experience painful swallowing or feel that the medicine is sticking in your throat.
TYLENOL® PM Extra Strength Liquid is a pain reliever and sleep aid that helps you fall asleep fast for a better night's sleep.
How long after eating is your stomach empty for medication?
As a general rule, medicines that are supposed to be taken on an empty stomach should be taken about an hour before a meal, or 2 hours after a meal. Forgetting these instructions on rare occasions is unlikely to do any harm, but taking these medicines with food regularly may mean they don't work.
Warnings: Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of. People with liver problems and children should take less acetaminophen.

Women taking daily amounts of non-aspirin painkillers — such as an extra-strength Tylenol — are more likely to develop high blood pressure than those who don't, a new study suggests.
Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (BP).
Extra Strength TYLENOL® Extra Strength Caplets | |
---|---|
ACTIVE INGREDIENT, DOSAGE* & DIRECTIONS | DOSAGE FREQUENCY* |
Acetaminophen 500 mg (in each caplet) | 2 caplets every 6 hours while symptoms last |
If you have no significant medical conditions and only take acetaminophen at recommended doses, then it is typically out of your system within 12 to 24 hours after your last dose. If you've been taking more than the recommended doses of acetaminophen, it could take a few days for your body to clear it.
Each tablet, capsule, or gelcap contains 500 milligrams (mg) of acetaminophen. Extra Strength Tylenol can be used in adults and children 12 years and over. The recommended dose is two tablets, capsules, or gelcaps every six hours as needed. The maximum daily dose is six tablets, capsules, or gelcaps.
Can I take Tylenol Arthritis every day? Yes, but you should be cautious. Acetaminophen, the main ingredient in Tylenol Arthritis, can cause liver damage if taken in large doses.
The pain relief and fever reduction abilities of acetaminophen typically last about four hours. If your pain does not get better or if your fever does not start to come down after one to two hours, contact your doctor or pharmacist or prescriber to see if you need a larger dose or a different medication.
Acetaminophen (Tylenol) is known as a non-aspirin pain reliever. It is NOT an NSAID, which is described below. Acetaminophen relieves fever and headaches, and other common aches and pains. It does not relieve inflammation.
Why do hospitals use Tylenol instead of ibuprofen?
Hospitals prefer acetaminophen -- the active ingredient in Tylenol -- because it has fewer side effects than aspirin. And they prefer Tylenol, says Consumer Reports in its June issue, because of the king-size discount the company offers hospitals.
In one meta-analysis, ibuprofen was found to be similar to or better than acetaminophen for treating pain and fever in adults and children. Both drugs were also found to be equally safe. One study in the analysis found that acetaminophen is safer with fewer side effects than ibuprofen.
What is the strongest type of Tylenol? The strongest forms of over-the-counter Tylenol are Tylenol 8-Hour Aches and Pain and 8-Hour Arthritis Pain. These products have 650 mg acetaminophen.
There are many reasons why a pill or capsule may appear undigested. It could be that the capsule has not broken down fully, though the active drug may have been absorbed. Or, you may have diarrhea or another disorder that causes a drug to pass through the intestines too quickly.
Some medicines can irritate the stomach, and taking them with food will reduce this effect. Things such as biscuits or a sandwich, or a glass of milk, are usually enough.